Predicted Lineups and Player News for Chelsea vs Ajax 22/10/25 - Champions League News

By Peter Guest, FootballPredictions.NET, 16:50 21/10/2025

The Champions League match on Wednesday will see Chelsea do battle with Ajax. Let’s check on the predicted line ups and player availability.

Chelsea are hoping to win again following the 0-3 Premier League victory versus Nottingham Forest. It seems likely that The Blues will probably employ a 4-2-3-1 formation for this one featuring Robert Sanchez, Reece James, Wesley Fofana, Tosin Adarabioyo, Marc Cucurella, Moises Caicedo, Romeo Lavia, Pedro Neto, Facundo Buonanotte, Alejandro Garnacho and Tyrique George.

Chelsea boss Enzo Maresca has zero fitness worries at all coming into this match owing to a fully injury-free squad available to choose from.

How Chelsea could look to take on Ajax

Following on from suffering a loss in their previous game against AZ in Eredivisie action, Ajax will be hoping to turn things around here. We reckon that de Godenzonen might make use of a 4-2-3-1 formation, giving starts to Vitezslav Jaros, Anton Gaaei, Josip Sutalo, Youri Baas, Lucas Rosa, Davy Klaassen, Kenneth Taylor, Oliver Edvardsen, Oscar Gloukh, Mika Godts and Wout Weghorst.

Owing to a fully healthy group available for selection, Ajax boss John Heitinga has no fitness worries to speak of coming into this clash.

Probable Ajax team

Hit the button below and see our detailed game preview, statistics, odds, h2h and prediction.