Predicted Lineups and Player News for Tottenham Hotspur vs Villarreal 16/09/25 - Champions League News

By Victor Martins, FootballPredictions.NET, 14:08 15/09/2025

Villarreal will face their next opponents on Tuesday which sees the Champions League tie against Tottenham Hotspur, so let’s look at the latest injury news and predicted line ups.

Tottenham Hotspur will be hoping for a repeat of their last result, following a 0-3 Premier League victory versus West Ham United. In our view, Spurs could use a 4-3-3 system for this game with Guglielmo Vicario, Pedro Porro, Cristian Romero, Micky van de Ven, Destiny Udogie, Lucas Bergvall, Archie Gray, Xavi Simons, Mohammed Kudus, Randal Kolo Muani and Brennan Johnson.

Tottenham Hotspur manager Thomas Frank will be grateful not to have any fitness worries to speak of ahead of this match thanks to a fully healthy group available to select from.

Possible Tottenham Hotspur team against Villarreal

Following on from a loss in their previous game against Atlético Madrid in La Liga competition, Villarreal and their fans will hope to get a better result this time. We’re of the thinking that El Submarino Amarillo seem likely to make use of a 4-2-3-1 lineup, starting the game with Luiz Júnior, Santiago Mouriño, Juan Foyth, Rafa Marín, Sergi Cardona, Pape Gueye, Thomas Partey, Nicolas Pepe, Santi Comesaña, Tajon Buchanan and Georges Mikautadze.

Owing to a completely healthy group available for selection, Villarreal manager Marcelino García Toral doesn’t have any fitness concerns to report coming into this game.

Likely Villarreal lineup

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